Recently, Jeyeraman et al . have proposed that the phenomenon of ultrasensitivity may be further subdivided into three sub-regimes, separated by sharp stimulus threshold values : OFF, OFF-ON-OFF, and ON . Based on their model, they proposed that this sub-regime of ultrasensitivity, OFF-ON-OFF, is like a switch-like adaption which can be accomplished by coupling N phosphorylation dephosphorylation cycles unidirectionally, without any explicit feedback loops.
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